USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: FLNA_HUMAN USC-OGP 2-DE database:  FLNA_HUMAN FLNA_HUMAN General information about the entry View entry in simple text format Entry name FLNA_HUMAN Primary accession number P21333 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Filamin-A; Short=FLN-A; AltName: Full=Actin-binding protein 280; Short=ABP-280; AltName: Full=Alpha-filamin; AltName: Full=Endothelial actin-binding protein; AltName: Full=Filamin-1; AltName: Full=Non-muscle filamin;. Gene name Name=FLNA Synonyms=FLN, FLN1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0020: pI=4.82; Mw=91938 SPOT OGP-0021: pI=4.73; Mw=90967 SPOT OGP-0022: pI=4.84; Mw=90967 SPOT OGP-0023: pI=4.80; Mw=90006 SPOT OGP-0024: pI=4.74; Mw=89529 SPOT OGP-0025: pI=4.86; Mw=89055 SPOT OGP-0026: pI=4.89; Mw=87648 SPOT OGP-0027: pI=4.94; Mw=85806 SPOT OGP-0037: pI=5.01; Mw=64787 SPOT OGP-0174: pI=4.91; Mw=27414 PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0278: pI=5.75; Mw=115322 SPOT OGP-0279: pI=5.77; Mw=114667 SPOT OGP-0280: pI=5.80; Mw=114015 SPOT OGP-0281: pI=5.85; Mw=113367 SPOT OGP-0282: pI=5.88; Mw=113367 SPOT OGP-0283: pI=5.91; Mw=112081 SPOT OGP-0284: pI=5.93; Mw=111444 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0607: pI=5.82; Mw=112081 SPOT OGP-0608: pI=5.85; Mw=110471 SPOT OGP-0609: pI=5.89; Mw=109410 SPOT OGP-0610: pI=5.94; Mw=109410 SPOT OGP-0611: pI=5.92; Mw=108359 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1352: pI=8.49; Mw=13705 Cross-references UniProtKB/Swiss-Prot P21333; FLNA_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name FLNA_HUMAN Primary accession number P21333 Secondary accession number(s) E9KL45 Q5HY53 Q5HY55 Q8NF52 Sequence was last modified on  January 23, 2007 (version 4) Annotations were last modified on  March 15, 2017 (version 218) Name and origin of the protein Description RecName: Full=Filamin-A; Short=FLN-A; AltName: Full=Actin-binding protein 280; Short=ABP-280; AltName: Full=Alpha-filamin; AltName: Full=Endothelial actin-binding protein; AltName: Full=Filamin-1; AltName: Full=Non-muscle filamin; Gene name Name=FLNA Synonyms=FLN, FLN1 Encoded on Name=FLNA; Synonyms=FLN, FLN1 Keywords 3D-structure; Acetylation; Actin-binding; Alternative splicing; Cilium biogenesis/degradation; Complete proteome; Cytoplasm; Cytoskeleton; Deafness; Direct protein sequencing; Disease mutation; Isopeptide bond; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X53416; CAA37495.1; -; mRNA EMBL L44140; AAA92644.1; -; Genomic_DNA EMBL X70082; CAA49687.1; -; Genomic_DNA EMBL X70085; CAA49690.1; -; Genomic_DNA EMBL GU727643; ADU87644.1; -; mRNA EMBL AK090427; BAC03408.2; ALT_INIT; mRNA EMBL AB593010; BAJ83965.1; -; mRNA EMBL BX664723; CAI43197.1; -; Genomic_DNA EMBL BX936346; CAI43197.1; JOINED; Genomic_DNA EMBL BX664723; CAI43199.1; -; Genomic_DNA EMBL BX936346; CAI43199.1; JOINED; Genomic_DNA EMBL BX936346; CAI43225.1; -; Genomic_DNA EMBL BX664723; CAI43225.1; JOINED; Genomic_DNA EMBL BX936346; CAI43227.1; -; Genomic_DNA EMBL BX664723; CAI43227.1; JOINED; Genomic_DNA EMBL CH471172; EAW72745.1; -; Genomic_DNA EMBL CH471172; EAW72746.1; -; Genomic_DNA CCDS CCDS44021.1; -. [P21333-2]; . CCDS CCDS48194.1; -. [P21333-1]; . PIR A37098; A37098; . RefSeq NP_001104026.1; NM_001110556.1. [P21333-1]; . RefSeq NP_001447.2; NM_001456.3. [P21333-2]; . UniGene Hs.195464; -; . PDB 2AAV; NMR; -; A=1863-1956 PDB 2BP3; X-ray; 2.32 A; A/B=1863-1956 PDB 2BRQ; X-ray; 2.10 A; A/B=2236-2329 PDB 2J3S; X-ray; 2.50 A; A/B=2045-2329 PDB 2JF1; X-ray; 2.20 A; A=2236-2329 PDB 2K3T; NMR; -; A=2427-2522 PDB 2K7P; NMR; -; A=1772-1956 PDB 2K7Q; NMR; -; A=1954-2141 PDB 2MTP; NMR; -; A=2236-2330 PDB 2W0P; X-ray; 1.90 A; A/B=2236-2329 PDB 2WFN; X-ray; 3.20 A; A/B=1-278 PDB 3CNK; X-ray; 1.65 A; A/B=2559-2647 PDB 3HOC; X-ray; 2.30 A; A/B=2-269 PDB 3HOP; X-ray; 2.30 A; A/B=2-269 PDB 3HOR; X-ray; 2.70 A; A/B=2-269 PDB 3ISW; X-ray; 2.80 A; A/B=2236-2329 PDB 3RGH; X-ray; 2.44 A; A/B=1158-1252 PDB 4M9P; X-ray; 1.72 A; A=478-766 PDB 4P3W; X-ray; 2.00 A; A/B/C/D/E/F=2152-2329 PDBsum 2AAV; -; . PDBsum 2BP3; -; . PDBsum 2BRQ; -; . PDBsum 2J3S; -; . PDBsum 2JF1; -; . PDBsum 2K3T; -; . PDBsum 2K7P; -; . PDBsum 2K7Q; -; . PDBsum 2MTP; -; . PDBsum 2W0P; -; . PDBsum 2WFN; -; . PDBsum 3CNK; -; . PDBsum 3HOC; -; . PDBsum 3HOP; -; . PDBsum 3HOR; -; . PDBsum 3ISW; -; . PDBsum 3RGH; -; . PDBsum 4M9P; -; . PDBsum 4P3W; -; . ProteinModelPortal P21333; -; . SMR P21333; -; . BioGrid 108605; 281; . DIP DIP-1136N; -; . IntAct P21333; 213; . MINT MINT-118283; -; . STRING 9606.ENSP00000358866; -; . TCDB 8.A.66.1.4; the dystrophin (dystrophin) family; . iPTMnet P21333; -; . PhosphoSitePlus P21333; -; . SwissPalm P21333; -; . BioMuta FLNA; -; . DMDM 116241365; -; . OGP P21333; -; . EPD P21333; -; . MaxQB P21333; -; . PaxDb P21333; -; . PeptideAtlas P21333; -; . PRIDE P21333; -; . Ensembl ENST00000360319; ENSP00000353467; ENSG00000196924. [P21333-2]; . Ensembl ENST00000369850; ENSP00000358866; ENSG00000196924. [P21333-1]; . Ensembl ENST00000422373; ENSP00000416926; ENSG00000196924. [P21333-2]; . GeneID 2316; -; . KEGG hsa:2316; -; . UCSC uc004fkk.3; human. [P21333-1]; . CTD 2316; -; . DisGeNET 2316; -; . GeneCards FLNA; -; . GeneReviews FLNA; -; . H-InvDB HIX0017150; -; . HGNC HGNC:3754; FLNA; . HPA CAB000356; -; . HPA HPA000368; -; . HPA HPA001016; -; . HPA HPA001115; -; . HPA HPA002925; -; . MalaCards FLNA; -; . MIM 300017; gene; . MIM 300048; phenotype; . MIM 300049; phenotype; . MIM 300244; phenotype; . MIM 300321; phenotype; . MIM 304120; phenotype; . MIM 305620; phenotype; . MIM 309350; phenotype; . MIM 311300; phenotype; . MIM 314400; phenotype; . neXtProt NX_P21333; -; . OpenTargets ENSG00000196924; -; . Orphanet 2301; Congenital short bowel syndrome; . Orphanet 1864; Congenital valvular dysplasia; . Orphanet 82004; Ehlers-Danlos syndrome with periventricular heterotopia; . Orphanet 323; FG syndrome; . Orphanet 1826; Frontometaphyseal dysplasia; . Orphanet 99811; Neuronal intestinal pseudoobstruction; . Orphanet 2484; Osteodysplasty; Melnick-Needles type; . Orphanet 90650; Otopalatodigital syndrome type 1; . Orphanet 90652; Otopalatodigital syndrome type 2; . Orphanet 98892; Periventricular nodular heterotopia; . Orphanet 88630; Terminal osseous dysplasia - pigmentary defects; . PharmGKB PA28172; -; . eggNOG KOG0518; Eukaryota; . eggNOG COG5069; LUCA; . GeneTree ENSGT00660000095431; -; . HOGENOM HOG000044235; -; . HOVERGEN HBG004163; -; . InParanoid P21333; -; . KO K04437; -; . OMA VQDNEGC; -; . OrthoDB EOG091G00U5; -; . PhylomeDB P21333; -; . TreeFam TF313685; -; . Reactome R-HSA-114608; Platelet degranulation; . Reactome R-HSA-430116; GP1b-IX-V activation signalling; . Reactome R-HSA-446353; Cell-extracellular matrix interactions; . Reactome R-HSA-5627123; RHO GTPases activate PAKs; . SignaLink P21333; -; . SIGNOR P21333; -; . ChiTaRS FLNA; human; . EvolutionaryTrace P21333; -; . GeneWiki FLNA; -; . GenomeRNAi 2316; -; . PMAP-CutDB P21333; -; . PRO PR:P21333; -; . Proteomes UP000005640; Chromosome X; . Bgee ENSG00000196924; -; . CleanEx HS_FLNA; -; . ExpressionAtlas P21333; baseline and differential; . Genevisible P21333; HS; . GO GO:0015629; C:actin cytoskeleton; IC:BHF-UCL; . GO GO:0005884; C:actin filament; IEA:Ensembl; . GO GO:0097440; C:apical dendrite; IEA:Ensembl; . GO GO:0005911; C:cell-cell junction; IDA:UniProtKB; . GO GO:0030863; C:cortical cytoskeleton; IEA:Ensembl; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0043198; C:dendritic shaft; IEA:Ensembl; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0031012; C:extracellular matrix; IDA:BHF-UCL; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:0005925; C:focal adhesion; IDA:UniProtKB; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0031523; C:Myb complex; IDA:MGI; . GO GO:0043025; C:neuronal cell body; IEA:Ensembl; . GO GO:0005730; C:nucleolus; IMP:CACAO; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl; . GO GO:0005886; C:plasma membrane; IDA:BHF-UCL; . GO GO:0030018; C:Z disc; ISS:BHF-UCL; . GO GO:0051015; F:actin filament binding; IDA:BHF-UCL; . GO GO:0045296; F:cadherin binding; IDA:BHF-UCL; . GO GO:0034988; F:Fc-gamma receptor I complex binding; IDA:BHF-UCL; . GO GO:0001664; F:G-protein coupled receptor binding; IPI:UniProtKB; . GO GO:0001948; F:glycoprotein binding; IDA:BHF-UCL; . GO GO:0051020; F:GTPase binding; IPI:UniProtKB; . GO GO:0044325; F:ion channel binding; IPI:BHF-UCL; . GO GO:0019900; F:kinase binding; IPI:UniProtKB; . GO GO:0015459; F:potassium channel regulator activity; IDA:BHF-UCL; . GO GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL; . GO GO:0048365; F:Rac GTPase binding; IDA:BHF-UCL; . GO GO:0017160; F:Ral GTPase binding; IDA:BHF-UCL; . GO GO:0017048; F:Rho GTPase binding; IDA:BHF-UCL; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0004871; F:signal transducer activity; IMP:UniProtKB; . GO GO:0031267; F:small GTPase binding; IDA:BHF-UCL; . GO GO:0008134; F:transcription factor binding; IPI:UniProtKB; . GO GO:0051764; P:actin crosslink formation; IDA:BHF-UCL; . GO GO:0031532; P:actin cytoskeleton reorganization; IDA:BHF-UCL; . GO GO:0007195; P:adenylate cyclase-inhibiting dopamine receptor signaling pathway; IMP:BHF-UCL; . GO GO:0034329; P:cell junction assembly; TAS:Reactome; . GO GO:0021987; P:cerebral cortex development; IEA:Ensembl; . GO GO:0060271; P:cilium assembly; IMP:UniProtKB; . GO GO:0051220; P:cytoplasmic sequestering of protein; IMP:BHF-UCL; . GO GO:0045184; P:establishment of protein localization; IDA:BHF-UCL; . GO GO:0021943; P:formation of radial glial scaffolds; IEA:Ensembl; . GO GO:0090307; P:mitotic spindle assembly; IDA:MGI; . GO GO:0042789; P:mRNA transcription from RNA polymerase II promoter; IEA:Ensembl; . GO GO:0043066; P:negative regulation of apoptotic process; IMP:CACAO; . GO GO:0042177; P:negative regulation of protein catabolic process; IMP:BHF-UCL; . GO GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IDA:UniProtKB; . GO GO:0016479; P:negative regulation of transcription from RNA polymerase I promoter; IDA:CACAO; . GO GO:0030168; P:platelet activation; TAS:Reactome; . GO GO:0070527; P:platelet aggregation; IMP:UniProtKB; . GO GO:0002576; P:platelet degranulation; TAS:Reactome; . GO GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB; . GO GO:2001046; P:positive regulation of integrin-mediated signaling pathway; IMP:CACAO; . GO GO:2000179; P:positive regulation of neural precursor cell proliferation; IEA:Ensembl; . GO GO:2001224; P:positive regulation of neuron migration; IEA:Ensembl; . GO GO:1901381; P:positive regulation of potassium ion transmembrane transport; IDA:BHF-UCL; . GO GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IMP:CACAO; . GO GO:0042993; P:positive regulation of transcription factor import into nucleus; IMP:UniProtKB; . GO GO:0034394; P:protein localization to cell surface; IDA:BHF-UCL; . GO GO:0072659; P:protein localization to plasma membrane; IDA:BHF-UCL; . GO GO:0050821; P:protein stabilization; IMP:BHF-UCL; . GO GO:0043113; P:receptor clustering; IDA:BHF-UCL; . GO GO:0030334; P:regulation of cell migration; IDA:UniProtKB; . GO GO:1905000; P:regulation of membrane repolarization during atrial cardiac muscle cell action potential; IC:BHF-UCL; . GO GO:1905031; P:regulation of membrane repolarization during cardiac muscle cell action potential; ISS:BHF-UCL; . GO GO:0071526; P:semaphorin-plexin signaling pathway; IGI:WormBase; . GO GO:0044319; P:wound healing; spreading of cells; IDA:UniProtKB CDD cd00014; CH; 2; . Gene3D 1.10.418.10; -; 2; . Gene3D 2.60.40.10; -; 24; . InterPro IPR001589; Actinin_actin-bd_CS; . InterPro IPR001715; CH-domain; . InterPro IPR017868; Filamin/ABP280_repeat-like; . InterPro IPR001298; Filamin/ABP280_rpt; . InterPro IPR028559; FLN_A; . InterPro IPR013783; Ig-like_fold; . InterPro IPR014756; Ig_E-set; . PANTHER PTHR11915:SF348; PTHR11915:SF348; 1; . Pfam PF00307; CH; 2; . Pfam PF00630; Filamin; 23; . SMART SM00033; CH; 2; . SMART SM00557; IG_FLMN; 24; . SUPFAM SSF47576; SSF47576; 1; . SUPFAM SSF81296; SSF81296; 24; . PROSITE PS00019; ACTININ_1; 1; . PROSITE PS00020; ACTININ_2; 1; . PROSITE PS50021; CH; 2; . PROSITE PS50194; FILAMIN_REPEAT; 24; .

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